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RESEARCH
AI-powered editorial analysis of peer-reviewed peptide studies. We translate complex science into clear takeaways — so you can understand what the research actually shows.
In adults with obesity, weekly Semaglutide injections produced average weight loss of 14.9% over 68 weeks, with 50% of participants achieving >15% weight reduction. Beyond weight loss, the GLP-1 receptor agonist improved cardiometabolic markers including blood pressure, lipids, and inflammatory markers, with cardiovascular event reductions in subsequent trials.
In obese adults, Tesofensine treatment produced dose-dependent weight loss of 4.5% to 9.2% over 24 weeks, significantly exceeding placebo (2% loss). The highest dose (1.0mg) achieved nearly 10% body weight reduction with improvements in waist circumference, blood pressure, and lipid profiles. Weight loss was attributed to both reduced appetite and increased energy expenditure.
MOTS-c treatment in mice prevented diet-induced obesity, improved insulin sensitivity, and enhanced exercise capacity. The peptide appeared to activate metabolic pathways in muscle and fat tissue, improving glucose uptake and energy expenditure even on a high-fat diet. Notably, MOTS-c levels decline with age, and supplementation restored metabolic function in older animals.
In patients with stable heart failure, SS-31 (Elamipretide) treatment improved mitochondrial respiration, reduced oxidative stress markers, and enhanced left ventricular function. Patients showed measurable improvements in exercise capacity and cardiac energetics, suggesting the peptide helps restore cellular energy production in stressed cardiac tissue.
In the first human brain imaging study of its kind, researchers found that Selank (anxiolytic) and Semax (nootropic) produce measurable changes in functional connectivity between the amygdala and temporal cortex regions within 5-20 minutes of administration, with each peptide showing both shared and unique connectivity patterns.
Kisspeptin-10 treatment restored reproductive function in hypothyroid male rats by normalizing elevated prolactin levels, increasing testosterone and LH, and improving sperm quality and testicular health.
NAD+ supplementation improved memory and reduced Alzheimer's pathology in mice by correcting abnormal RNA splicing patterns through a protein called EVA1C, which was found to be reduced in the hippocampus of Alzheimer's patients compared to cognitively normal individuals.
Copper peptide GHK-Cu combined with LED light therapy significantly increased fibroblast collagen synthesis in laboratory studies, demonstrating synergistic effects between peptide treatment and photobiomodulation.
